Protein Details: Amiloride-sensitive sodium channel subunit alpha
Protein ID
ICDB_Pro_1030
Protein Name
Amiloride-sensitive sodium channel subunit alpha
Gene Name
Scnn1a
Organism
Mus musculus (Mouse)
Length
699 amino acids
AlphaFoldDB
AF-Q61180-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney; colon; lung and eccrine sweat glands. Also plays a role in taste perception.
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Expressed in kidney (at protein level) (PubMed:22207244). Expressed in lung (at protein level) (PubMed:22207244; PubMed:30659401). Expressed in the epididymis (at protein level) (PubMed:30659401). Expressed in the epididymis (at protein level) (PubMed:30659401). Expressed in the epididymis (at protein level) (PubMed:30659401). In the caput and corpus regions of the epididymis; expressed uniformly on the luminal and basal surfaces of the ducts and in the sperm in the duct lumen (PubMed:30659401). Also expressed in distal colon and; at low levels; in liver (PubMed:10409305).
DOI ID
10.1152/ajprenal.1999.277.1.f121; 10.1203/00006450-199709000-00013; 10.1074/jbc.c000906200; 10.1096/fj.02-0497fje; 10.1074/jbc.m402820200; 10.1074/jbc.m110.103432; 10.1007/s00418-011-0904-1; 10.1007/s10735-019-09813-3
RefSeq
NP_035454.2